Respiratory failure & ventilation
Association Between Mechanical Power During Prone Positioning and Mortality in Patients With Acute Respiratory Distress Syndrome
Main finding · Change in mechanical power during prone positioningResult — go to the resultHazard ratio 1.071 95% CI 1.020–1.125Authors' conclusion
Dynamic increases in mechanical power during prone positioning are linked to higher ICU mortality in ARDS patients.
Study context
- Population
- Acute respiratory distress syndrome (ARDS) patients undergoing prone positioning on invasive mechanical ventilation, Peking Union Medical College Hospital
- Participants
- 1,078 patients
- Exposure
- Increased vs non-increased mechanical power during prone positioning; nonsurvivors vs survivors
- Outcome
- Change in mechanical power during prone positioning
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
Hazard ratio
1.071
95% CI 1.020–1.125
P = 0.007
Change by group
Nonsurvivors
0.8 × 10 −2
median · IQR −3.3 to 5.6 × 10 −2 J/min/kg · J/min/kg
Survivors
−0.6 × 10 −2
median · IQR −4.9 to 3.3 × 10 −2 J/min/kg · J/min/kg
Per 10-U increase in 10 −2 J/kg/min, as printed
- ICU mortality overall
- 20.9% (225/1078)
Observational data: associations, not effects.
Further findings
Mortality, increased vs non-increased mechanical power
- ICU mortality (p = 0.011)
- 23.9% vs. 17.8%
- In-hospital mortality (p = 0.018)
- 25.2% vs. 19.5%
- 28-day mortality (p = 0.002)
- 33.2% vs. 25.4%
In-hospital and 28-day mortality risk, ventilator-free days (multivariable)
- Increased mechanical power independently associated with higher in-hospital and 28-day mortality risk and fewer ventilator-free days
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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