Perioperative medicine & outcomes
Association between Preoperative Depression and Length of Stay after Major Surgery: A Systematic Review and Meta-analysis
Pooled resultResult — go to the resultMean difference 0.98 days 95% CI 0.35–1.62Authors' conclusion
This meta-analysis demonstrated that patients with a history of depression or active depressive symptoms before surgery had longer postoperative hospitalization, although evidence was limited by risk of bias and publication bias.
Study context
- Population
- Adults undergoing inpatient surgery
- Participants
- 27,708,719 adults · 57 studies
- Comparison
- Preoperative depression vs no depression
- Outcome
- MD in postoperative LOS between patients with and without depression
Methodological detailsmultilevel random-effects meta-analysis, Grading of Recommendations Assessment, Development and Evaluation (GRADE), ROBINS-E risk of bias, 26 prospective and 31 retrospective studies
- Multilevel random-effects meta-analysis
- GRADE
- ROBINS-E risk of bias
- 26 prospective and 31 retrospective studies
Pooled result
As reported in the abstract
Mean difference
0.98 days
95% CI 0.35–1.62
Depression vs No depression
mean difference 0.98 days (95% CI 0.35–1.62)
Further pooled results
| Outcome | Estimate | |
|---|---|---|
| Extended LOS, unadjusted | OR 1.31 (95% CI 0.94–1.82) | |
| Extended LOS, adjusted | aOR 1.27 (95% CI 1.11–1.46) | |
| 0.512Ratio (log scale) |
Original publication
Association between Preoperative Depression and Length of Stay after Major Surgery: A Systematic Review and Meta-analysis. Anesthesiology. Published 19 June 2025. doi:10.
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