Perioperative medicine & outcomes
The association between preoperative serum cholinesterase and all-cause mortality in geriatric patients with hip fractures: a cohort study of 2387 patients
Authors' conclusion
Preoperative cholinesterase levels were nonlinearly associated with mortality in elderly hip fractures, and cholinesterase was a risk indicator of all-cause mortality.
Study context
- Population
- Elderly patients with hip fractures screened Jan 2015–Sep 2019
- Participants
- 2,387 patients
- Exposure
- Preoperative serum cholinesterase level
- Outcome
- All-cause mortality
- Follow-up
- Mean 37.64 months
Methodological detailsmultivariate Cox regression, nonlinear analysis, propensity score-matching sensitivity analysis
- Multivariate Cox regression
- Nonlinear analysis
- Propensity score-matching sensitivity analysis
Main finding
As reported in the abstract
All-cause mortality per 1000 U/L increase in preoperative cholinesterase
Hazard ratio (95% CI)P value
Cholinesterase per 1000 U/L (linear)linear association unstable; nonlinearity identified
0.83(0.78–0.88)
P < 0.0001Cholinesterase < 5940 U/L, per 1000 U/Lmortality decreased by 28% per 1000 U/L increase
0.72(0.66–0.79)
P < 0.0001Cholinesterase > 5940 U/Lmortality no longer decreased with rise of cholinesterase
1.01(0.91–1.11)
P = 0.9157Each row per its own increment, as printed
- Inflection point of cholinesterase concentration
- 5940 U/L
- Deaths from all causes
- 787 (33.0%)
Observational data: associations, not effects.
Further findings
Nonlinear association, propensity score-matching sensitivity analysis
- Nonlinear association very stable
Original publication
The association between preoperative serum cholinesterase and all-cause mortality in geriatric patients with hip fractures: a cohort study of 2387 patients. Perioper Med (Lond). Published 24 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →