Association between red blood cell distribution width and 30-day mortality in critically ill septic patients: a propensity score-matched study
Main finding · 30-day mortalityResult — go to the resultHazard ratio 1.887 95% CI 1.847–1.928Authors' conclusion
We found that RDW was associated with 30-day mortality in critically ill septic patients, underscoring the potential as a prognostic marker in sepsis.
Study context
- Population
- Critically ill adults with sepsis on the TriNetX platform, excluding hematologic malignancies, thalassemia and iron deficiency anemia40.0% RDW ≥16%
- Participants
- 256,387 adults
- Exposure
- High RDW vs lower RDW
- Outcome
- 30-day mortality
- Follow-up
- 30 days
Methodological detailspropensity-score matched (1:1), TriNetX platform
- Propensity-score matched (1:1)
- TriNetX platform
Main finding
As reported in the abstract
Hazard ratio
1.887
95% CI 1.847–1.928
High RDW vs Lower RDW
HR 1.887 (95% CI 1.847–1.928)
Observational data: associations, not effects.
Further findings
30-day mortality by RDW cut-point (sensitivity analysis)
- Cut-point 12%
- 2.098
- Cut-point 14%
- 2.204
- Cut-point 16%
- 1.887
- Cut-point 18%
- 1.809
- Cut-point 20%
- 1.932
- Consistent associations
30-day mortality by sepsis severity (subgroup)
- Shock
- 1.731
- Mechanical ventilation
- 1.735
- Bacteremia
- 2.380
- Hemodialysis
- 1.979
- Consistent associations
Original publication
Association between red blood cell distribution width and 30-day mortality in critically ill septic patients: a propensity score-matched study. J Intensive Care. Published 18 September 2024. doi:10.
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