Perioperative medicine & outcomes

Association between surgical start time and postoperative mortality, morbidity and healthcare utilisation in elective non‐cardiac surgeries: a retrospective, single‐centre study using propensity score matching

AnaesthesiaPublished Retrospective cohort study

Main finding · MortalityResult — go to the resultAdjusted hazard ratio 1.33 95% CI 1.07–1.66

Authors' conclusion

Surgical start timing was an independent risk factor for increased short- and long-term postoperative mortality, morbidity and healthcare resource utilisation.

Study context

Population
Patients undergoing elective non-cardiac surgery
Participants
291,051 patients
Exposure
Afternoon vs morning surgical start time
Outcome
Surgical outcomes: mortality, morbidity and healthcare utilisation
Methodological detailssingle-centre, propensity score matching
  • Single-centre
  • Propensity score matching

Main finding

Mortality · 30 days

Adjusted hazard ratio

1.33

95% CI 1.07–1.66

P = 0.010

By group

Afternoon vs Morning
aHR 1.33 (95% CI 1.07–1.66); P = 0.010

As reported in the abstract

Observational data: associations, not effects.

Further findings

OutcomeMorningAfternoonEstimateP value
Mortality · 1 year2.73%3.36%aHR 1.26 (95% CI 1.20–1.32)P < 0.001
Composite complications5.48%5.94%aOR 1.05 (95% CI 1.01–1.08)P = 0.010
ICU admission5.87%7.18%aOR 1.09 (95% CI 1.06–1.13)P < 0.001
Intra-operative transfusion3.40%4.10%aOR 1.27 (95% CI 1.21–1.33)P < 0.001
  • Mortality: unadjusted p < 0.001
  • Composite complications: unadjusted p = 0.003
  • ICU admission: unadjusted p < 0.001
  • Intra-operative transfusion: unadjusted p < 0.001

Restricted mean survival time

Significantly shorter survival times in the afternoon group across all time points

High-risk patients and surgery type (subgroup)

Impact of start time more pronounced in high-risk patients and varied significantly by type of surgery

Original publication

Association between surgical start time and postoperative mortality, morbidity and healthcare utilisation in elective non‐cardiac surgeries: a retrospective, single‐centre study using propensity score matching. Anaesthesia. Published 22 September 2025. doi:10.1111/anae.16788

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