Cardiothoracic & vascular anesthesia
The Effects of Daytime Variation on Short-Term Outcomes of Cardiac Surgical Patients: A PRISMA-Compliant Systemic Review and Meta-Analysis
Pooled resultResult — go to the resultOdds ratio 1.09 95% CI 0.99–1.21Authors' conclusion
These findings suggest that circadian influences on elective cardiac surgical outcomes are limited.
Study context
- Population
- Patients who underwent elective cardiac surgery, cardiovascular centers
- Participants
- 135,672 patients · 14 observational studies
- Comparison
- Morning vs afternoon cardiac surgery
- AMn = 81,391
- Afternoon (AF)n = 54,281reference
- Outcome
- Hospitalized mortality
Methodological detailsPRISMA-compliant
- PRISMA-compliant
Pooled result
As reported in the abstract
Odds ratio
1.09
95% CI 0.99–1.21
P = 0.08
Events by group
AM vs AF
OR 1.09 (95% CI 0.99–1.21); P = 0.08
Further pooled results
| Outcome | AM | AF | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| New-onset atrial fibrillation | 26.05% | 25.50% | 1.11 (1.01–1.21) | P = 0.03 | |
| Denominator | 8,907 | 3,921 | |||
| 0.512Odds ratio (log scale) |
MI, stroke, renal and infectious complications, reexploration, mechanical circulatory support
- Incidences comparable between AM and AF
Mechanical ventilation duration
- No significant difference; MD (hours), 95% CI
- MD = −0.20 hours, 95% CI = −0.40 to 0.00; p = 0.05
ICU LOS
- No significant difference; MD (hours), 95% CI
- MD = −0.35 hours, 95% CI = −6.14 to 5.43; p = 0.90
Hospital LOS
- No significant difference; MD (days), 95% CI
- MD = −0.10 days, 95% CI = −0.39 to 0.19; p = 0.49
Original publication
The Effects of Daytime Variation on Short-Term Outcomes of Cardiac Surgical Patients: A PRISMA-Compliant Systemic Review and Meta-Analysis. J Cardiothorac Vasc Anesth. Published 25 November 2025. doi:10.
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