Perioperative medicine & outcomes

Impact of daily, weekly, and seasonal surgical timing on postoperative outcomes in high-risk patients undergoing elective non-cardiac surgery: A retrospective, single-center study

J Clin AnesthPublished Retrospective cohort study

Authors' conclusion

Surgical start timing was significantly associated with postoperative outcomes in high-risk patients, underscoring the need for strategic scheduling.

Study context

Population
High-risk patients (ASA ≥ 3) undergoing elective non-cardiac surgery at a tertiary medical center, 2012 to 2021
Participants
14,394 patients
Exposure
Afternoon vs morning surgical start time
Outcome
Mortality
Methodological detailssingle-centre
  • Single-centre

Main finding

As reported in the abstract

Afternoon vs MorningAdjusted hazard ratio (95 % CI)P value
90 days
1.28(1.05–1.57)
P = 0.016
180 days
1.30(1.12–1.51)
P < 0.001
1 year
1.26(1.13–1.40)
P < 0.001
Overall mortality
1.16(1.09–1.23)
P < 0.001

Observational data: associations, not effects.

Further findings

OutcomeaOR (95 % CI)P value
Composite complications1.21 (1.11–1.33)P < 0.001
ICU admission1.40 (1.28–1.52)P < 0.001
RBC transfusion1.40 (1.22–1.61)P < 0.001

Start 3:00-6:00 p.m. (highest risk interval)

EstimateP value
3:00-6:00 p.m.1-year mortalityaHR 1.33 (95 % CI 1.15–1.54)P < 0.001
3:00-6:00 p.m.Composite complicationsaOR 1.32 (95 % CI 1.17–1.50)P < 0.001

Seasonal mortality

aHR (95 % CI)P value
Summer30-day mortality1.80 (1.08–2.99)P = 0.023
Summer90-day mortality1.32 (1.00–1.74)P = 0.048
WinterOverall mortality1.10 (1.01–1.19)P = 0.030

Subgroups by surgical type (subgroup)

Variability by surgical type

Original publication

Impact of daily, weekly, and seasonal surgical timing on postoperative outcomes in high-risk patients undergoing elective non-cardiac surgery: A retrospective, single-center study. J Clin Anesth. Published 26 May 2025. doi:10.1016/j.jclinane.2025.111879

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