Association between the timing of intensive care unit (ICU) admission and mortality in patients with hospital-onset sepsis: a nationwide prospective cohort study
Authors' conclusion
Among patients with hospital-onset sepsis, in-hospital mortality did not differ significantly between those with early and delayed ICU admission.
Study context
- Population
- Patients with hospital-onset sepsis admitted to the ICUs of 19 tertiary hospitals, September 2019 to December 202019 tertiary hospitals
- Participants
- 286 vs 470
- Exposure
- Delayed vs early ICU admission
- Delayedn = 286
- Earlyn = 470reference
- Outcome
- In-hospital mortality
Methodological detailsnationwide, multicentre, 1:1 propensity-score matched, adjusted logistic regression
- Nationwide
- Multicentre
- 1:1 propensity-score matched
- Adjusted logistic regression
Main finding
As reported in the abstract
Delayed vs EarlyAdjusted odds ratio (95% CI)
Unmatched cohort
1.35(0.99–1.85)
Matched cohort
1.38(0.94–2.02)
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | |
|---|---|---|
| In-hospital mortality, increasing lactate levels (subgroup)P for interaction = 0.003 | 2.10 (1.37–3.23) | |
| In-hospital mortality, septic shock (subgroup)P for interaction = 0.019 | 2.06 (1.31–3.22) | |
| In-hospital mortality, mechanical ventilation on day of ICU admission (subgroup)P for interaction = 0.027 | 1.92 (1.24–2.96) | |
| In-hospital mortality, vasopressor support on day of ICU admission (subgroup)P for interaction = 0.042 | 1.69 (1.17–2.44) | |
| 0.20.5125Adjusted odds ratio (log scale) |
- In-hospital mortality, increasing lactate levels (subgroup): P for interaction = 0.003
- In-hospital mortality, septic shock (subgroup): P for interaction = 0.019
- In-hospital mortality, mechanical ventilation on day of ICU admission (subgroup): P for interaction = 0.027
- In-hospital mortality, vasopressor support on day of ICU admission (subgroup): P for interaction = 0.042
Original publication
Association between the timing of ICU admission and mortality in patients with hospital-onset sepsis: a nationwide prospective cohort study. J Intensive Care. Published 21 April 2023. doi:10.
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