Impact of the timing of invasive mechanical ventilation in patients with sepsis: a multicenter cohort study
Main finding · ICU mortalityResult — go to the resultOdds ratio 0.66 95% CI 0.47–0.93Authors' conclusion
In patients with sepsis ventilated in ICU, earlier start (first day of ICU admission) of MV may be associated with lower mortality.
Study context
- Population
- Adults with sepsis receiving mechanical ventilation (MV) in the intensive care unit (ICU), Korean Sepsis Alliance, 20 hospitals in Korea, September 2019–December 2021295 per group matched
- Participants
- 2,440 adults
- Exposure
- Early MV vs delayed MV
- Early MVn = 295
- Delayed MVn = 295reference
- Outcome
- ICU mortality
Methodological detailspropensity-score matched, multicentre registry
- Propensity-score matched
- Multicentre registry
Main finding
As reported in the abstract
Odds ratio
0.66
95% CI 0.47–0.93
P = 0.015
By group
Early MV vs Delayed MV
OR 0.66 (95% CI 0.47–0.93); P = 0.015
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| ICU mortality (multivariable logistic regression) | 0.38 (0.29–0.50) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
In-hospital mortality, ICU LOS, tracheostomy
- Early MV: lower in-hospital mortality, shorter ICU stay, less frequent tracheostomy vs delayed MV
Original publication
Impact of the timing of invasive mechanical ventilation in patients with sepsis: a multicenter cohort study. Crit Care. Published 9 September 2024. doi:10.
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