In-hospital development of new-onset frailty and discharge outcomes among patients with sepsis: a Korean multicenter registry study
Authors' conclusion
New-onset frailty and in-hospital death were common among patients with sepsis who were non-frail at baseline.
Study context
- Population
- Adults with sepsis without baseline frailty (premorbid Clinical Frailty Scale score < 5), Korean Sepsis Alliance registry, 15 hospitals in South Korea
- Participants
- 6,336 adults · 15 hospitals
- Exposure
- Discharge outcome categories among patients non-frail at baseline
- New-onset frailtyn = 1,453
- In-hospital deathn = 1,527
- Outcome
- Discharge outcome: non-frail at discharge, new-onset frailty at discharge, or in-hospital death
- Follow-up
- Discharge
Methodological detailsprospectively maintained registry, multinomial logistic regression, competing outcome (in-hospital death)
- Prospectively maintained registry
- Multinomial logistic regression
- Competing outcome (in-hospital death)
Main finding
As reported in the abstract
Incidence of new-onset frailty and in-hospital death
- Older age (per 1-SD increase) associated with new-onset frailty, aOR
- 1.38
- Higher Charlson Comorbidity Index (per 1-SD increase) associated with new-onset frailty, aOR
- 1.27
- Higher SOFA score (per 1-SD increase) associated with new-onset frailty, aOR
- 1.41
- ICU admission associated with new-onset frailty, aOR
- 1.47
- Pulmonary infection associated with new-onset frailty, aOR
- 1.77
Observational data: associations, not effects.
Further findings
- Home discharge among hospital survivors with new-onset frailty
- 42.8%
Factors associated with in-hospital death
- Several of these factors also associated with in-hospital death, with a larger adjusted estimate for SOFA score
Factors associated with home discharge in new-onset frailty (exploratory)
- Higher SOFA score, solid malignancy, and nursing home- or nursing hospital-acquired infection associated with lower likelihood of home discharge
- Exploratory analysis
New-onset frailty associations, inverse probability of censoring weighting (sensitivity analysis)
- Overall pattern of associations remained generally consistent
Original publication
In-hospital development of new-onset frailty and discharge outcomes among patients with sepsis: a Korean multicenter registry study. J Intensive Care. Published 13 July 2026. doi:10.
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