Postintensive Care Frailty of Older Patients With Septic Shock: A Post Hoc Analysis of a Multicenter Randomized Controlled Trial
Authors' conclusion
Baseline frailty before sepsis, organ dysfunction severity, and corticosteroid therapy independently predict severe postintensive care frailty in older adults with septic shock.
Study context
- Population
- Adults ≥65 years with septic shock in ICUs in Japan, from an RCT of BP targets339 survived to 90 days
- Participants
- 513 adults
- Comparison
- Postintensive care frailty categories at 90 days
- No-to-mild frailtyn = 103
- Moderate frailtyn = 114
- Severe frailtyn = 122
Methodological detailspost hoc analysis, multicentre
- Post hoc analysis
- Multicentre
Primary result
As reported in the abstract
Factors independently associated with postintensive care frailty (ordinal logistic regression, generalized estimating equation model) · 90 days
Adjusted odds ratio (CI)P value
Higher presepsis CFS scoresper 1-point increase
2.03(1.72–2.40)
P < 0.001Higher sequential organ failure assessment (SOFA) scoresper 1-point increase
1.16(1.06–1.26)
P < 0.001Corticosteroid use
1.72(1.14–2.61)
P < 0.001Per 1-point increase, as printed
Further findings
Subgroup analyses (subgroup)
- Corticosteroid use associated with frailty deterioration in patients with baseline frailty (Clinical Frailty Scale (CFS) ≥ 5)
- Sequential organ failure assessment (SOFA) scores associated with frailty in patients with tissue hypoperfusion (lactate ≥ 2 mmol/L)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Postintensive Care Frailty of Older Patients With Septic Shock: A Post Hoc Analysis of a Multicenter Randomized Controlled Trial. Crit Care Med. Published 12 August 2026. doi:10.
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