Cardiothoracic & vascular anesthesia
Association Between the Use of Midazolam During Cardiac Anesthesia and the Incidence of Postoperative Delirium: A Retrospective Cohort Study Using a Nationwide Database
Main finding · Postoperative deliriumResult — go to the resultOdds ratio 0.95 95% CI 0.87–1.03Authors' conclusion
Intraoperative administration of midazolam may not induce postoperative delirium in patients undergoing cardiac surgery.
Study context
- Population
- Patients aged ≥65 years undergoing cardiovascular surgery (excluding transcatheter, multiple surgeries per admission, preoperative delirium), Japanese Diagnosis Procedure Combination database, April 2015–October 2019analysed
- Participants
- 16,185 patients
- Exposure
- Intraoperative midazolam vs no midazolam
- Midazolamn = 10,633
- Outcome
- Incidence of postoperative delirium
Methodological detailsnationwide database, stabilized inverse probability of treatment weighting, propensity score, Sensitivity analyses supported these results
- Nationwide database
- Stabilized inverse probability of treatment weighting
- Propensity score
- Sensitivity analyses supported these results
Main finding
Postoperative delirium
Odds ratio
0.95
95% CI 0.87–1.03
P = 0.21
Midazolam vs No midazolam
OR 0.95 (95% CI 0.87–1.03); P = 0.21
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Hospital mortality | 0.92 (0.76–1.11) | P = 0.39 | |
| PONV | 0.92 (0.85–0.99) | P = 0.03 | |
| 0.512Odds ratio (log scale) |
ICU LOS
P < 0.001
Hospital LOS
P < 0.001
Original publication
Association Between the Use of Midazolam During Cardiac Anesthesia and the Incidence of Postoperative Delirium: A Retrospective Cohort Study Using a Nationwide Database. J Cardiothorac Vasc Anesth. Published 27 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →