Association of continuous renal replacement therapy downtime with fluid balance gap and clinical outcomes: a retrospective cohort analysis utilizing electronic health records (EHR) and machine data
Main finding · Association of FBgap with %TTL, by alarm frequency (subgroup)Result — go to the resultΒ per 1% increase in %TTL 0.87 95% CI 0.48–1.26Authors' conclusion
In critically ill adult patients undergoing CRRT, %TTL was associated with FBgap only in the subgroup with higher alarm frequency, but not in the other subgroups with lower alarms. No association between %TTL and mortality was observed.
Study context
- Population
- Critically ill adults receiving continuous renal replacement therapy (CRRT)3,630 CRRT patient-days
- Participants
- 500 adults
- Exposure
- CRRT downtime and FBgap, hospital mortality
- Outcome
- FBgap (achieved minus prescribed fluid balance) and hospital mortality in relation to %TTL
Methodological detailsEHR and CRRT machine data
- EHR and CRRT machine data
Main finding
As reported in the abstract
Association of FBgap with %TTL, by alarm frequency (subgroup)
Β per 1% increase in %TTL
0.87
95% CI 0.48–1.26
Observational data: associations, not effects.
Further findings
Hospital mortality
- No statistical evidence for an association between %TTL and hospital mortality (adjusted model with alarm-frequency interaction)
%TTL and FBgap (cohort)
- Median %TTL (IQR 4.3-12.5)
- 8.1%
- Median FBgap, mL/kg/day (IQR 8.2-30.4)
- 17.4
Original publication
Association of continuous renal replacement therapy downtime with fluid balance gap and clinical outcomes: a retrospective cohort analysis utilizing EHR and machine data. J Intensive Care. Published 31 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →