Hemodynamics, fluids & transfusion
Association of cumulative fluid balance trajectories with haemodynamics, inflammation, and long-term mortality in critically ill patients with circulatory failure
Authors' conclusion
There is substantial heterogeneity of cumulative fluid balance trajectories in critically ill patients with circulatory failure.
Study context
- Population
- Critically ill patients with acute circulatory failure, Salzburg Intensive Care databaseincluded in the analysis
- Participants
- 1,702 patients
- Exposure
- Latent classes of cumulative fluid balance trajectories over first 7 days after ICU admission
- Outcome
- Cumulative fluid balance trajectory classes and their association with haemodynamics, inflammation and adjusted mortality
- Follow-up
- First 7 days after ICU admission; mortality within 180 days
Methodological detailsgrowth mixture models (latent process mixed models), single database (Salzburg Intensive Care database)
- Growth mixture models (latent process mixed models)
- Single database (Salzburg Intensive Care database)
Main finding
As reported in the abstract
Cumulative fluid balance trajectories · first 7 days after ICU admission
Five distinct classes of cumulative fluid balance trajectories, diverging in slope and shape
5
Trajectory consistent with four-phase concept
567
33.3%
Observational data: associations, not effects.
Original publication
Association of cumulative fluid balance trajectories with haemodynamics, inflammation, and long-term mortality in critically ill patients with circulatory failure. Br J Anaesth. Published 2 December 2025. doi:10.
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