Cardiothoracic & vascular anesthesia
Association of Acute Systemic Inflammation with Patient-Centric Postoperative Pulmonary Complications After Elective Cardiac Surgery
Authors' conclusion
Acute systemic inflammation is significantly associated with PPCs after elective cardiac surgery in adults when taking into consideration preoperative inflammatory burden and perioperative factors that may influence postoperative lung injury.
Study context
- Population
- Adults undergoing elective cardiac surgery175 analysed
- Participants
- 204 adults
- Exposure
- POD 1 biomarkers of inflammation (IL-6, IL-8, TNF-α) and alveolar epithelial injury (sRAGE) vs moderate/severe postoperative pulmonary complications (PPCs)
- Outcome
- Moderate or severe PPCs, graded using a validated scale
- Follow-up
- POD 0 to 7
Main finding
As reported in the abstract
Moderate/severe PPCs (adjusted for baseline biomarker values and lung injury risk factors)
Odds ratio (95% CI)P value
POD 1 IL-8, per 50 pg/mL increase
7.19(2.13–28.53)
P = 0.003POD 1 IL-6, per 50 pg/mL increase
1.42(1.13–1.93)
P = 0.01Per 50 pg/mL increase, as printed
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Multiplicative increase in hours of ventilation (95% CI) | P value | |
|---|---|---|---|
| Postoperative ventilation duration (log-transformed, linear regression)Adjusted analyses | 25% (2%–52%) | P = 0.03 | |
| −50050100Difference (linear scale) |
Postoperative ventilation duration (log-transformed, linear regression)
- TNF-α not significantly associated with ventilation duration
Original publication
Association of Acute Systemic Inflammation with Patient-Centric Postoperative Pulmonary Complications After Elective Cardiac Surgery. Anesth Analg. Published 8 August 2024. doi:10.
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