Cardiothoracic & vascular anaesthesia
Plasma Amyloid-β 1-40 and Postoperative Delirium After Cardiac Surgery
Authors' conclusion
In this prospective cohort study, preoperative Aβ1-40 showed the strongest association with POD risk among the measured biomarkers.
Study context
- Population
- Patients ≥50 years undergoing elective cardiac surgery at a comprehensive cardiac surgery center in Germany, 2021–2022491 completed postoperative delirium (POD) assessment
- Participants
- 504 patients
- Exposure
- Preoperative plasma Alzheimer disease biomarkers and POD
- PODn = 106
- Outcome
- POD (Confusion Assessment Method algorithm, assessed daily)
- Follow-up
- 5 days postoperatively
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
POD
POD
21.6%
106
- Aβ1-40, independent biomarker most strongly associated with POD: AUC
- 0.65 (95% CI 0.59-0.71; P < .001)
- Biomarkers + clinical factors: AUC
- 0.74 (95% CI 0.69-0.79; P < .001)
- Clinical factors alone: AUC
- 0.73 (95% CI 0.67-0.78; P < .001)
- Combined model incl. Montreal Cognitive Assessment (MoCA), driven primarily by Aβ1-40: AUC
- 0.77 (95% CI 0.72-0.82; P < .001)
Observational data: associations, not effects.
Further findings
Baseline cognition (lower MoCA scores), multiple linear regression
- pTau217: β
- −0.51 (95% CI −0.89 to −0.12; P = .01)
- Age: β
- −0.12 (95% CI −0.16 to −0.08; P < .001)
Original publication
Plasma Amyloid-β 1-40 and Postoperative Delirium After Cardiac Surgery. JAMA Netw Open. Published 1 July 2026. doi:10.
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