Cardiothoracic & vascular anesthesia
Association Between Plasma Neurofilament Light Concentration and Postoperative Delirium After Cardiac Surgery
Authors' conclusion
Preoperative plasma NFL concentration was associated with POD, whereas changes in NFL were not.
Study context
- Population
- Patients aged ≥65 years scheduled for elective cardiac surgery with CPB
- Participants
- 151 patients
- Exposure
- Perioperative plasma NFL concentration and postoperative delirium (POD)
- PODn = 60
- Outcome
- Association of log(NFL) with POD
Methodological detailssingle-centre, Plasma NFL measured at induction and 6 hours postoperatively
- Single-centre
- Plasma NFL measured at induction and 6 hours postoperatively
Main finding
As reported in the abstract
- Baseline and postoperative log(NFL) significantly associated with delirium
- Perioperative changes in NFL not associated with delirium
- Baseline log(NFL) remained an independent predictor of POD in multivariable analysis
Observational data: associations, not effects.
Further findings
Incidence of POD · 7 days
- Delirium occurred
- 60 (40%)
Perioperative changes in NFL and POD
- Perioperative changes in NFL not significantly associated with delirium
Clinical factors associated with POD
- POD associated with congestive HF, lower educational status, more erythrocyte transfusion, complex procedures, prolonged deep anesthesia and intraoperative burst suppression
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association Between Plasma Neurofilament Light Concentration and Postoperative Delirium After Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 6 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →