Cardiothoracic & vascular anesthesia
Association of perioperative plasma concentration of neurofilament light with delirium after cardiac surgery: a nested observational study
Main finding · Baseline neurofilament light concentration and deliriumResult — go to the resultOdds ratio 1.027 95% CI 1.003–1.053Authors' conclusion
Baseline neurofilament light concentration, but not change from baseline to postoperative day 1, was associated with delirium after cardiac surgery.
Study context
- Population
- Cardiac surgery patients in a trial of arterial BP targeting during CPB using cerebral autoregulation metrics
- Participants
- 175 patients
- Exposure
- Delirious vs non-delirious patients
- Outcome
- Postoperative delirium
Methodological detailsnested in a trial of arterial BP targeting during CPB
- Nested in a trial of arterial BP targeting during CPB
Main finding
As reported in the abstract
Baseline neurofilament light concentration and delirium · Baseline
Odds ratio
1.027
95% CI 1.003–1.053
P = 0.029
By group
Greater baseline neurofilament light
OR 1.027 (95% CI 1.003–1.053); P = 0.029
- Delirium incidence
- 44.6%
Observational data: associations, not effects.
Further findings
Delirium severity
- Greater baseline neurofilament light associated with delirium severity (adjusted)
Change in neurofilament light from baseline to POD 1
- Neurofilament light increase from baseline to POD 1
- 42%
- No association with delirium
Original publication
Association of perioperative plasma concentration of neurofilament light with delirium after cardiac surgery: a nested observational study. Br J Anaesth. Published 19 December 2023. doi:10.
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