Respiratory failure & ventilation
Association of Breathing Effort With Survival in Patients With Acute Respiratory Distress Syndrome
Authors' conclusion
Patients who die of ARDS are more likely to be exposed to high respiratory effort for prolonged periods of time compared with survivors.
Study context
- Population
- Acute respiratory distress syndrome (ARDS) patients on mechanical ventilation, during 7 days after onset of spontaneous breathing1,485,405 respiratory cycles
- Participants
- 26 patients
- Exposure
- ICU nonsurvivors vs survivors
- Nonsurvivorsn = seven
- Survivorsn = 19reference
- Outcome
- Time in high effort
Methodological detailscontinuous recording over 7 days, variance weighted analysis
- Continuous recording over 7 days
- Variance weighted analysis
Main finding
As reported in the abstract
P = 0.006
Observational data: associations, not effects.
Further findings
Time in moderate-effort range
P < 0.001
Time with high dynamic transpulmonary driving pressure (> 25 cm H 2 O)
P = 0.001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Association of Breathing Effort With Survival in Patients With Acute Respiratory Distress Syndrome. Crit Care Med. Published 5 August 2025. doi:10.
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