Association of Genetic Variants with Postsurgical Pain: A Systematic Review and Meta-analyses
Authors' conclusion
Despite much published data, only two alleles have a small association with postsurgical pain.
Study context
- Population
- Adult surgical patients; studies of genetic variants and postsurgical pain (PubMed, Embase, Cochrane CENTRAL, 2000–2022)163 studies
- Outcome
- Association of genetic variants with acute (0 to 48 h) or chronic (≥3 months) postsurgical pain (pain score or analgesic/opioid consumption)
Pooled result
As reported in the abstract
Association of genetic variants with postsurgical pain
OPRM1 rs1799971, acute postsurgical opioid use: SMD
0.25
95% CI 0.16 to 0.35; cohort size 8,227
OPRM1 rs1799971, acute postsurgical pain score: SMD
0.20
95% CI 0.09 to 0.31; cohort size 4,619
COMT rs4680, chronic postsurgical pain score: SMD
0.26
95% CI 0.08 to 0.44; cohort size 1,726
Original publication
Association of Genetic Variants with Postsurgical Pain: A Systematic Review and Meta-analyses. Anesthesiology. Published 29 September 2023. doi:10.
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