Genetic variants associated with chronic postsurgical pain: evidence from the China Surgery and Anaesthesia Cohort study
Authors' conclusion
This study enhances our understanding of the genetic predisposition to chronic postsurgical pain.
Study context
- Population
- Surgical patients in the China Surgery and Anaesthesia Cohort9,022 genotyped
- Participants
- 17,025 patients
- Outcome
- CPSP, dichotomous (yes, no) or continuous (based on pain intensity, Brief Pain Inventory) across surgeries
- Follow-up
- 3 months
Methodological detailsgenome-wide association analyses, polygenic risk scores
- Genome-wide association analyses
- Polygenic risk scores
Main finding
As reported in the abstract
Genetic loci associated with CPSP
Independent genome-wide significant loci associated with chronic postsurgical pain (CPSP)
16
SNP-based narrow-sense heritability, CPSP as continuous variable
13.7%
5.1–22.4%
Observational data: associations, not effects.
Further findings
Polygenic risk scores
- PRS of post-traumatic stress disorder, pain all over the body, multisite chronic pain and opioid dependence associated with CPSP at nominal significance
Original publication
Genetic variants associated with chronic postsurgical pain: evidence from the China Surgery and Anaesthesia Cohort study. Br J Anaesth. Published 26 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →