Preoperative psychological symptoms and chronic postsurgical pain: analysis of the prospective China Surgery and Anaesthesia Cohort study
Authors' conclusion
The presence of preoperative psychological symptoms might individually or jointly increase the risk of chronic postsurgical pain or experiencing deterioration in pain trajectory.
Study context
- Population
- Surgery patients aged 40–65 yr from two medical centres, China Surgery and Anaesthesia Cohort, July 2020–March 20231,302 with chronic postsurgical pain (CPSP)
- Participants
- 8,350 patients
- Exposure
- Preoperative psychological symptoms vs minor symptom pattern
- Outcome
- Chronic postsurgical pain (CPSP)
Methodological detailsmulticentre, k-means clustering analysis, mediation analysis
- Multicentre
- K-means clustering analysis
- Mediation analysis
Main finding
As reported in the abstract
CPSP
Each group vs minor symptomOdds ratio (95% CI)
Sleep disturbances
1.46(1.25–1.70)
Multiple psychological symptoms
1.84(1.48–2.28)
Observational data: associations, not effects.
Further findings
CPSP, anxiety (individual symptom)
| OR (95% CI) | ||
|---|---|---|
| AnxietyMost pronounced individual symptom | 1.52 (1.23–1.86) | |
| 0.512Odds ratio (log scale) |
| Outcome | OR (95% CI) | |
|---|---|---|
| Increasing pain trajectory within 3 monthsSleep disturbances vs Minor symptom | 1.58 (1.20–2.08) | |
| Increasing pain trajectory within 3 monthsMultiple psychological symptoms vs Minor symptom | 4.34 (3.20–5.88) | |
| 0.20.5125Odds ratio (log scale) |
Mediation analyses
- Acute/subacute postsurgical pain and psychological symptoms 1 month after surgery were notable mediators of the associations
Original publication
Preoperative psychological symptoms and chronic postsurgical pain: analysis of the prospective China Surgery and Anaesthesia Cohort study. Br J Anaesth. Published 11 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →