Cardiothoracic & vascular anesthesia
Association of hypoxemia during one-lung ventilation and postoperative complications: A retrospective cohort study
Main finding · Composite of severe pulmonary complicationsResult — go to the resultOdds ratio 1.21 95% CI 1.02–1.44Authors' conclusion
Cumulative hypoxemia during OLV is independently associated with increased risk of severe postoperative pulmonary complications.
Study context
- Population
- Adults (≥18 years) undergoing thoracic surgery with one-lung ventilation (OLV), January 2017–February 2022
- Participants
- 2,748 adults
- Exposure
- Cumulative hypoxemic burden during OLV
- Outcome
- Composite of severe pulmonary complications (reintubation, prolonged mechanical ventilation, ARDS, extended non-invasive ventilatory support, pneumonia)
Methodological detailsmultivariable logistic regression
- Multivariable logistic regression
Main finding
Composite of severe pulmonary complications
Odds ratio
1.21
95% CI 1.02–1.44
AUC of SpO2 < 90%
OR 1.21 (95% CI 1.02–1.44)
Per 1% x hour increase in AUC, as printed
As reported in the abstract
- Incidence of severe pulmonary complications
- 2.5%
Observational data: associations, not effects.
Secondary outcomes
AKI
| OR (95% CI) | P value | ||
|---|---|---|---|
| AUC of hypoxemia | 1.14 (0.96–1.36) | P = 0.130 | |
| 0.512Odds ratio (log scale) |
AF
| OR (95% CI) | P value | ||
|---|---|---|---|
| AUC of hypoxemia | 0.94 (0.71–1.25) | P = 0.680 | |
| 0.512Odds ratio (log scale) |
Delirium
| OR (95% CI) | P value | ||
|---|---|---|---|
| AUC of hypoxemia | 1.10 (0.82–1.48) | P = 0.523 | |
| 0.512Odds ratio (log scale) |
All-cause mortality · five years
| HR (95% CI) | P value | ||
|---|---|---|---|
| AUC of hypoxemia | 0.95 (0.77–1.17) | P = 0.620 | |
| 0.512Hazard ratio (log scale) |
Original publication
Association of hypoxemia during one-lung ventilation and postoperative complications: A retrospective cohort study. Anaesth Crit Care Pain Med. Published 7 November 2025. doi:10.
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