Cardiothoracic & vascular anesthesia
Association between inspired oxygen fraction and development of postoperative pulmonary complications in thoracic surgery: a multicentre retrospective cohort study
Authors' conclusion
Our results do not support limiting the inspired oxygen fraction for the purpose of reducing postoperative pulmonary complications in thoracic surgery involving one-lung ventilation.
Study context
- Population
- Adults undergoing thoracic surgical procedures using OLV, four US medical centres
- Participants
- 2,716 adults · 2,733 procedures
- Exposure
- High intraoperative fraction (FiO2) and postoperative pulmonary complications (PPCs)
- Outcome
- Composite of PPCs (atelectasis, ARDS, pneumonia, respiratory failure, reintubation, prolonged ventilation >48 h)
Methodological detailsmulticentre, two integrated perioperative databases
- Multicentre
- Two integrated perioperative databases
Main finding
As reported in the abstract
PPCs
Procedures resulting in PPCs
141 of 2733
5.2%
FiO2 univariately associated with PPCs, aOR
1.17
95% CI 1.04–1.33P=0.012
Time-weighted average FiO2 not associated with PPCs in logistic regression, aOR
1.01
95% CI 1.00–1.02P=0.165
Observational data: associations, not effects.
Further findings
Duration of OLV and PPCs (logistic regression)
- Duration of OLV associated with PPCs, aOR
- 1.20 (95% CI 1.03-1.41, P=0.022)
Original publication
Association between inspired oxygen fraction and development of postoperative pulmonary complications in thoracic surgery: a multicentre retrospective cohort study. Br J Anaesth. Published 11 September 2024. doi:10.
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