Cardiothoracic & vascular anesthesia
Effects of intraoperative inspired oxygen fraction (FiO2 0.3 vs 0.8) on patients undergoing off-pump coronary artery bypass grafting: the CARROT multicenter, cluster-randomized trial
Primary result · Length of hospital stayResult — go to the resultSub-distribution HR 0.98 95% CI 0.83–1.16Authors' conclusion
In patients undergoing OPCAB, intraoperative administration of 80% oxygen did not decrease the length of hospital stay, compared to 30% oxygen, but may reduce postoperative acute kidney injury.
Study context
- Population
- Patients undergoing off-pump coronary artery bypass grafting (OPCAB) in three tertiary hospitals, August 2019 to August 2021cluster-randomised
- Participants
- 414 patients
- Comparison
- Intraoperative FiO2 30% vs 80% oxygen
- Primary endpoint
- Length of hospital stay
Methodological detailscluster-randomised, multicentre, Cluster-randomised by month of surgery
- Cluster-randomised
- Multicentre
- Cluster-randomised by month of surgery
Primary result
As reported in the abstract
Sub-distribution HR
0.98
95% CI 0.83–1.16
P = 0.808
By group
30% oxygen vs 80% oxygen
sub-distribution HR 0.98 (95% CI 0.83–1.16); P = 0.808
Further findings
| Outcome | 30% oxygen | 80% oxygen | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Postoperative AKI | 30.7% | 19.4% | 1.94 (1.18–3.17) | P = 0.036 | |
| 0.20.5125Odds ratio (log scale) |
Intraoperative time-weighted average mixed venous oxygen saturation
P < 0.001
Intraoperative time-weighted average cerebral regional oxygen saturation
P = 0.002
Original publication
Effects of intraoperative inspired oxygen fraction (FiO2 0.3 vs 0.8) on patients undergoing off-pump coronary artery bypass grafting: the CARROT multicenter, cluster-randomized trial. Crit Care. Published 13 July 2023. doi:10.
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