Cardiothoracic & vascular anesthesia
Low versus High Fraction of Inspired Oxygen During Lung Separation in Thoracic Surgery: A Randomized Controlled Trial
Authors' conclusion
A strategy of low FiO2 before and after lung separation did not improve the oxygenation capacity of the lungs, and lung collapse was comparable in the 2 study groups. However, the occurrence of PPC was significantly reduced in the group treated with low FiO2.
Study context
- Population
- Patients scheduled for thoracic surgery requiring one-lung ventilation (OLV), university hospital53 analysed
- Participants
- 55 patients
- Comparison
- Low oxygen content vs Pure oxygen
- Primary endpoint
- PaO2/FiO2 ratio
- Follow-up
- 30 minutes after the start of OLV
Methodological detailsprospective, nonblinded, single-centre
- Prospective
- Nonblinded
- Single-centre
Primary result
As reported in the abstract
- PaO2/fraction of inspired oxygen (FiO2) ratio comparable in the 2 groups
Secondary outcomes
- Incidence of postoperative pulmonary complications (PPC) — PPC incidence, low oxygen content strategy vs comparator · significantly reduced with low oxygen content strategy
- 19% vs 48% · P = 0.042
Lung collapse (none, partial or complete) during early OLV
- Similar in the 2 groups
Original publication
Low versus High Fraction of Inspired Oxygen During Lung Separation in Thoracic Surgery: A Randomized Controlled Trial. J Cardiothorac Vasc Anesth. Published 20 March 2025. doi:10.
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