Cardiothoracic & vascular anesthesia
Inspired Oxygen Concentration During the Re-initiation of Two-Lung Ventilation in Thoracic Surgery: A Post Hoc Analysis of Data From the Multicenter Perioperative Outcomes Group
Primary result · PPCs, average FiO2 during lung reinflation (multivariable logistic regression)Result — go to the resultAdjusted odds ratio 1.14 10% FiO 2 increment 95% CI 1.01–1.29Authors' conclusion
The results of this study suggest a unique sensitivity to alveolar hyperoxia at the time of lung reinflation and raise the possibility that restricting the inspired oxygen fraction during lung reinflation could reduce injury and related sequelae.
Study context
- Population
- Thoracic surgery patients with single-lung ventilation, Multicenter Perioperative Outcomes Group data
- Comparison
- Average FiO2 during lung reinflation
- Primary endpoint
- PPCs
Methodological detailspost hoc, multivariable logistic regression
- Post hoc
- Multivariable logistic regression
Primary result
As reported in the abstract
PPCs, average FiO2 during lung reinflation (multivariable logistic regression)
Adjusted odds ratio
1.14 10% FiO 2 increment
95% CI 1.01–1.29
P = 0.032
Average inspired oxygen fraction during the period of lung reinflation
aOR 1.14 10% FiO 2 increment (95% CI 1.01–1.29); P = 0.032
Further findings
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| PPCs by duration of single-lung ventilation (per hour)Same multivariable model | 1.21 (1.03–1.42) | P = 0.020 | |
| 0.512Adjusted odds ratio (log scale) |
Original publication
Inspired Oxygen Concentration During the Re-initiation of Two-Lung Ventilation in Thoracic Surgery: A Post Hoc Analysis of Data From the Multicenter Perioperative Outcomes Group. Anesth Analg. Published 10 March 2025. doi:10.
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