Perioperative medicine & outcomes
Association of preoperative beta-blocker interruption on postoperative morbidity and mortality: a historical cohort study
Authors' conclusion
Results from this study suggest that preoperative acute beta-blocker interruption is significantly associated with decreased 30-day and 90-day postoperative all-cause mortality.
Study context
- Population
- Consecutive patients on beta-blockers undergoing elective surgery at two hospitals in Ontario, Canada, 2014–201822.2% with interruption
- Participants
- 4,971 patients
- Exposure
- Beta-blocker interruption vs Continued
- Outcome
- 30-day and 90-day mortality
- Follow-up
- 30 and 90 days
Methodological detailstwo hospitals, single academic institution, consecutive patients, propensity covariate-adjusted logistic regression
- Two hospitals, single academic institution
- Consecutive patients
- Propensity covariate-adjusted logistic regression
Main finding
As reported in the abstract
Beta-blocker interruption vs ContinuedOdds ratio (95% CI)P value
30-day mortality, adjusted
0.42(0.18–1.00)
P = 0.04990-day mortality, adjusted
0.51(0.28–0.90)
P = 0.02Observational data: associations, not effects.
Secondary outcomes
Secondary outcomes (composite of adverse events)
- After adjustment, beta-blocker interruption not significantly associated with any secondary outcome
Original publication
Association of preoperative beta-blocker interruption on postoperative morbidity and mortality: a historical cohort study. Can J Anaesth. Published 24 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →