Perioperative medicine & outcomes
Association of preoperative beta-blocker use and cardiac complications after major noncardiac surgery: a prospective cohort study
Main finding · Cardiac PMIResult — go to the resultWeighted odds ratio 1.03 95% CI 0.94–1.12Authors' conclusion
Preoperative use of beta-blockers was not associated with decreased cardiac complications including cardiac perioperative myocardial infarction or injury and major adverse cardiac event. Additionally, preoperative use of beta-blockers was not associated with increased all-cause death within 30 and 365 days.
Study context
- Population
- Consecutive patients at elevated cardiovascular risk undergoing major noncardiac surgerymean age 74 yr
- Participants
- 10,272 patients
- Exposure
- Preoperative beta-blocker use vs no beta-blocker
- Beta-blockersn = 3,839
- Outcome
- Perioperative MI or injury attributable to a cardiac cause (cardiac PMI)
- Follow-up
- First three postoperative days
Methodological detailsmulticentre, inverse probability of treatment weighting, central adjudication, Cardiac complications prospectively monitored and centrally adjudicated by two independent experts
- Multicentre
- Inverse probability of treatment weighting
- Central adjudication
- Cardiac complications prospectively monitored and centrally adjudicated by two independent experts
Main finding
Cardiac PMI
Weighted odds ratio
1.03
95% CI 0.94–1.12
P = 0.55
Beta-blockers vs No beta-blockers
weighted OR 1.03 (95% CI 0.94–1.12); P = 0.55
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Weighted HR (95% CI) | P value | |
|---|---|---|---|
| MACE (MI, acute HF, life-threatening arrhythmia, cardiovascular death) · 365 days | 0.99 (0.83–1.18) | P = 0.90 | |
| 0.512Weighted hazard ratio (log scale) |
- Major adverse cardiac events (MACE) (MI, acute HF, life-threatening arrhythmia, cardiovascular death) — MACE overall
- 971/10 272 (9.5%)
Original publication
Association of preoperative beta-blocker use and cardiac complications after major noncardiac surgery: a prospective cohort study. Br J Anaesth. Published 15 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →