Association of pronounced elevation of NET formation and nucleosome biomarkers with mortality in patients with septic shock
Authors' conclusion
The nucleosome levels showed correlation with neutrophil count, IL-6 and were found to be independently associated with mortality assessed at day 5 or 28.
Study context
- Population
- Patients with septic shock (sepsis-3 definition)
- Participants
- 151 patients
- Exposure
- Septic shock patients vs control group; survivors vs non-survivors
- Septic shockn = 151
- Outcome
- Nucleosome H3.1 levels and association with mortality
- Follow-up
- 28 days
Main finding
As reported in the abstract
Nucleosome H3.1 levels and mortality
- Nucleosome H3.1 levels markedly and significantly elevated at all time points in septic shock vs control
- Significantly higher values (day 1-2 and 3-4) in non-survivors (28-day mortality); still significant after multivariate analysis, more pronounced with highest concentration
Observational data: associations, not effects.
Further findings
Immunological parameters (inflammation and immunosuppression)
- IL-6 at day 1-2 (tremendous early inflammation)
- 1335 pg/mL
- mHLA-DR at day 3-4 (marked immunosuppression)
- 3853 AB/C
- CD4 at day 3-4
- 338 cell /µL
Correlation of nucleosome levels with organ failure and severity scores, IL-6 and neutrophil count
- Significantly positive correlation
5-day mortality
- Early increased nucleosome levels independently associated with 5-day mortality
Correlation of nucleosome levels with mHLA-DR · day 6-8
- Persistent elevated nucleosome levels negatively correlated with mHLA-DR
Original publication
Association of pronounced elevation of NET formation and nucleosome biomarkers with mortality in patients with septic shock. Ann Intensive Care. Published 17 October 2023. doi:10.
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