Association of systolic, diastolic, mean, and pulse pressure with morbidity and mortality in septic intensive care unit (ICU) patients: a nationwide observational study
Authors' conclusion
Blood pressure component association with ICU mortality is the strongest for mean followed by systolic, diastolic, and weakest for pulse pressure.
Study context
- Population
- Septic ICU patients in 364 ICUs, eICU Research Institute database
- Participants
- 77,328 patients · 364 ICUs
- Exposure
- Lowest cumulative mean, systolic, diastolic and pulse pressure sustained ≥120 min during ICU stay
- Outcome
- ICU mortality
Methodological detailsmulticentre database (eICU Research Institute), multivariable logistic regression spline and threshold regression
- Multicentre database (eICU Research Institute)
- Multivariable logistic regression spline and threshold regression
Main finding
As reported in the abstract
- Change-point, mean pressure
- 69 mmHg
- Change-point, systolic pressure
- 100 mmHg
- Change-point, diastolic pressure
- 60 mmHg
- Change-point, pulse pressure
- 57 mmHg
- Threshold regression slope, mean pressure
- - 0.13
- Threshold regression slope, systolic pressure
- - 0.11
- Threshold regression slope, diastolic pressure
- - 0.09
- Threshold regression slope, pulse pressure
- - 0.05
Observational data: associations, not effects.
Secondary outcomes
Composite AKI or death and myocardial injury or death during ICU stay
- Similar relationship between BP components and secondary outcomes
ICU mortality in septic shock (sensitivity analysis, n = 4211)
- Equivalent non-linear associations between BP components and ICU mortality confirmed
Original publication
Association of systolic, diastolic, mean, and pulse pressure with morbidity and mortality in septic ICU patients: a nationwide observational study. Ann Intensive Care. Published 20 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →