ICU sedation, delirium & recovery
Associations Between Physical, Cognitive, and Mental Health Domains of Post-Intensive Care Syndrome and Quality of Life: A Longitudinal Multicenter Cohort Study
Authors' conclusion
PICS symptoms in the physical, cognitive, and mental domains are all negatively associated with changes in HRQoL at 3 and 12 months post-ICU.
Study context
- Population
- ICU patients from seven Dutch ICUs
- Participants
- 4,092 patients · 7 Dutch ICUs
- Outcome
- Associations of physical, cognitive and mental post-intensive care syndrome (PICS) health domains with changes in HRQoL
- Follow-up
- 3 and 12 months post-ICU
Methodological detailslongitudinal, multicentre
- Longitudinal
- Multicentre
Main finding
As reported in the abstract
Association of PICS domains with change in HRQoL (adjusted multivariable linear regression)
- Physical health problems, 3 months (n = 3368): β
- −0.04 (95% CI −0.06 to 0.02; p < 0.001)
- Cognitive health problems, 3 months (n = 3368): β
- −0.05 (95% CI −0.09 to −0.02; p < 0.001)
- Mental health problems, 3 months (n = 3368): β
- −0.08 (95% CI −0.10 to −0.05; p < 0.001)
- Physical health problems, 12 months (n = 2950): β
- −0.06 (95% CI −0.08 to −0.03; p < 0.001)
- Cognitive health problems, 12 months (n = 2950): β
- −0.04 (95% CI −0.08 to −0.01; p < 0.015)
- Mental health problems, 12 months (n = 2950): β
- −0.06 (95% CI −0.08 to −0.03; p < 0.001)
Observational data: associations, not effects.
Original publication
Associations Between Physical, Cognitive, and Mental Health Domains of Post-Intensive Care Syndrome and Quality of Life: A Longitudinal Multicenter Cohort Study. Crit Care Med. Published 24 October 2024. doi:10.
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