Perioperative medicine & outcomes
Associations of intraoperative end–tidal CO2 levels with postoperative outcome–secondary analysis of a worldwide observational study
Primary result · PPCs (composite)Result — go to the resultRelative risk 1.00 95 % CI 0.94–1.06Authors' conclusion
In this cohort of patients at high risk of PPCs, the overall occurrence of PPCs was not different between 'low etCO2' patients and 'normal to high etCO2' patients, but severe PPCs occurred more often in 'low etCO2', with an inverse dose-dependent relationship between intraoperative etCO2 levels and PPCs.
Study context
- Population
- Patients at high risk of postoperative pulmonary complications (PPCs) receiving intraoperative ventilation during GA
- Participants
- 1,843 vs 648
- Comparison
- Low end-tidal CO2 (etCO2) vs normal to high etCO2
- Low etCO2n = 1,843
- Normal to high etCO2n = 648reference
- Primary endpoint
- Composite of previously defined PPCs
Methodological detailsinternational, propensity score matching, LOESS regression
- International
- Propensity score matching
- LOESS regression
Primary result
PPCs (composite)
Relative risk
1.00
95 % CI 0.94–1.06
P = 0.84
By group
Low etCO2 vs normal to high etCO2
RR 1.00 (95 % CI 0.94–1.06); P = 0.84
As reported in the abstract
Secondary outcomes
%
| Outcome | Low etCO2 | Normal to high etCO2 | RR (CI) | P value | |
|---|---|---|---|---|---|
| Proportion of severe PPCs among total occurring PPCsPropensity score matching did not change these findings | 35 | 18 | 1.16 (1.08–1.25) | P < 0.001 | |
| 0.512Relative risk (log scale) |
Relationship of lowest etCO2 with PPCs (LOESS)
- Inverse relationship of intraoperative etCO2 levels with occurrence of PPCs
Original publication
Associations of intraoperative end–tidal CO2 levels with postoperative outcome–secondary analysis of a worldwide observational study. J Clin Anesth. Published 19 December 2024. doi:10.
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