Perioperative medicine & outcomes
Sex dependence of postoperative pulmonary complications – A post hoc unmatched and matched analysis of LAS VEGAS
Primary result · PPCs, unmatched cohortResult — go to the resultOdds ratio 0.93 CI 0.81–1.06Authors' conclusion
In this conveniently-sized worldwide cohort of patients receiving intraoperative ventilation under general anaesthesia for surgery, the PPC incidence was not significantly different between sexes.
Study context
- Population
- Patients undergoing intraoperative ventilation under GA for surgerymatched cohort 6154
- Participants
- 9,697 patients
- Comparison
- Females vs males
- Femalesn = 5,342
- Malesn = 4,355reference
- Primary endpoint
- Composite of postoperative pulmonary complications (PPCs)
- Follow-up
- First 5 postoperative days
Methodological detailspost hoc, unmatched and propensity-score matched analysis, international, 146 hospitals across 29 countries
- Post hoc
- Unmatched and propensity-score matched analysis
- International
- 146 hospitals across 29 countries
Primary result
PPCs, unmatched cohort
Odds ratio
0.93
CI 0.81–1.06
P = 0.255
By group
Females
10.0
%
Males
10.7%
Females vs Males
OR 0.93 (CI 0.81–1.06); P = 0.255
As reported in the abstract
Secondary outcomes
| Outcome | Females | Males | OR (CI) | P value | |
|---|---|---|---|---|---|
| PPCs, matched cohortPropensity-score matched cohort (3077 vs 3077) · matched cohort | 10.5 % | 10.0% | 1.05 (0.89–1.25) | P = 0.556 | |
| 0.512Odds ratio (log scale) |
New invasive ventilation, unmatched cohort
- Occurred less often in females in the unmatched cohort
Hospital LOS and mortality
- Similar between females and males in both cohorts
Original publication
Sex dependence of postoperative pulmonary complications – A post hoc unmatched and matched analysis of LAS VEGAS. J Clin Anesth. Published 23 September 2024. doi:10.
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