Perioperative medicine & outcomes
Postoperative Acute Kidney Injury by Age and Sex: A Retrospective Cohort Association Study
Authors' conclusion
Younger females display a lower odds of postoperative AKI that gradually increases with age.
Study context
- Population
- Adult inpatients without pre-existing end-stage kidney disease undergoing index major noncardiac, nonkidney/urologic surgery, 2013–2019
- Participants
- 390,382 inpatients · 46 institutions
- Exposure
- Age and sex groups: females >50 yr, males ≤50 yr, males >50 yr vs females ≤50 yr
- Females ≤50 yrn = 58,585reference
- Males ≤50 yrn = 55,503
- Males >50 yrn = 132,447
- Outcome
- Postoperative AKI by Kidney Disease-Improving Global Outcomes serum creatinine criteria
Methodological detailsmulticentre, 46 institutions
- Multicentre
- 46 institutions
Main finding
As reported in the abstract
Each group vs females ≤50 yrOdds ratio (95% CI)
Females >50 yr
1.51(1.43–1.59)
Males ≤50 yr
1.90(1.79–2.01)
Males >50 yr
2.06(1.96–2.17)
- Overall postoperative acute kidney injury (AKI)
- 25,809 (6.6%)
Observational data: associations, not effects.
Original publication
Postoperative Acute Kidney Injury by Age and Sex: A Retrospective Cohort Association Study. Anesthesiology. Published 10 November 2022. doi:10.
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