Associations of Synaptosome‐associated Protein 25 Gene Polymorphism, Autonomic Nervous System Activity, and Recovery of Consciousness from Propofol Anesthesia
Authors' conclusion
Genetic variation in SNAP-25 gene is associated with the recovery of consciousness and autonomic nervous system activity during propofol anesthesia.
Study context
- Population
- Preoperative patients volunteering for a simulated propofol anesthesia procedure
- Participants
- 130 patients
- Comparison
- SNAP-25 rs6039822 G/G vs A/A genotype
- Outcome
- Recovery time of verbal commands
Methodological detailssimulated anesthesia procedure, Sanger genotyping
- Simulated anesthesia procedure
- Sanger genotyping
Main finding
As reported in the abstract
P = 0.048
Further findings
Independent factors for recovery of verbal commands (logistic regression)
- SNAP-25 rs6039822 and sex independent factors (chi-square = 11.916; P = 0.008)
Other consciousness indices, concentrations (Ce), heart rate variability, peripheral perfusion index · recovery
- Support resistance of the SNAP-25 rs6039822 variant to anesthetic during recovery
Original publication
Associations of Synaptosome‐associated Protein 25 Gene Polymorphism, Autonomic Nervous System Activity, and Recovery of Consciousness from Propofol Anesthesia. Anesthesiology. Published 19 June 2025. doi:10.
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