Hemodynamics, fluids & transfusion
Balanced Solution Versus Normal Saline in Predicted Severe Acute Pancreatitis: A Stepped Wedge Cluster Randomized Trial
Primary resultResult — go to the resultDifference −4.3 mmol/L 95% CI −5.6 to −3.0Authors' conclusion
Among patients with pSAP, using BMES in preference to NS resulted in a significantly more physiological serum chloride level, which was associated with multiple clinical benefits
Study context
- Population
- Patients with predicted severe acute pancreatitis (APACHE II score ≥8 and C-reactive protein >150 mg/L) admitted within 72 hours of symptom onset
- Participants
- 259 patients · 11 sites
- Comparison
- BMES vs normal saline (NS) for intravenous fluid
- BMESn = 112
- NSn = 147reference
- Primary endpoint
- Serum chloride concentration
- Follow-up
- Trial day 3
Methodological detailsmulticentre, stepped-wedge, cluster-randomised, one-way crossover
- Multicentre
- Stepped-wedge
- Cluster-randomised
- One-way crossover
Primary result
As reported in the abstract
Difference
−4.3 mmol/L
95% CI −5.6 to −3.0
P < 0.001
By group
BMES vs NS
difference −4.3 mmol/L (95% CI −5.6 to −3.0); P < 0.001
Secondary outcomes
Systemic inflammatory response syndrome · trial day 7
P = 0.024
Organ failure-free days · trial day 7
P < 0.001
Days alive and out of ICU · trial day 30
P = 0.009
Days alive and out of hospital · trial day 30
P < 0.001
Original publication
Balanced Solution Versus Normal Saline in Predicted Severe Acute Pancreatitis: A Stepped Wedge Cluster Randomized Trial. Ann Surg. Published 6 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →