Baricity of spinal bupivacaine and the incidence of hypotension in non-obstetric surgery: A systematic review
Authors' conclusion
While the literature suggests a trend towards greater incidence of hypotension with hyperbaric bupivacaine, no statistically significant difference was found.
Study context
- Population
- Patients receiving spinal anaesthesia with bupivacaine for non-obstetric surgery
- Participants
- 586 patients · 10 randomised controlled trials (RCTs)
- Comparison
- Isobaric vs hyperbaric spinal bupivacaine
- Outcome
- Haemodynamic sequelae of spinal anaesthesia (incidence of hypotension)
Methodological detailsPRISMA guidelines, MEDLINE and EMBASE search up to February 2024, Variations in bupivacaine doses and volumes, spinal techniques and definitions of hypotension hindered definitive conclusions
- PRISMA guidelines
- MEDLINE and EMBASE search up to February 2024
- Variations in bupivacaine doses and volumes, spinal techniques and definitions of hypotension hindered definitive conclusions
Pooled result
As reported in the abstract
Incidence of hypotension
- Trend towards greater incidence of hypotension with hyperbaric bupivacaine; no statistically significant difference
Original publication
Baricity of spinal bupivacaine and the incidence of hypotension in non-obstetric surgery: A systematic review. Eur J Anaesthesiol Intensive Care. Published 13 December 2024. doi:10.
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