Respiratory failure & ventilation
Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study
Authors' conclusion
Rapid identification of ARDS inflammatory subphenotypes using a near-patient assay was feasible and associated with many clinical characteristics and outcomes consistent with those described in earlier retrospective studies, including mortality, prevalence of sepsis, and incidence of metabolic acidosis.
Study context
- Population
- Adults ≥18 years with acute respiratory distress syndrome (ARDS) or acute hypoxaemic respiratory failure within 72 h of onset, on invasive mechanical ventilation, NIV or high-flow nasal oxygen, intensive care units (ICUs) in the UK and Ireland490 subphenotyped
- Participants
- 512 adults
- Exposure
- Hyperinflammatory vs hypoinflammatory ARDS subphenotype
- Hyperinflammatoryn = 89
- Hypoinflammatoryn = 401reference
- Outcome
- 60-day mortality
- Follow-up
- 60 days
Methodological detailsmulticentre, prospective near-patient subphenotyping, 30 centres; enrolment Nov 22, 2019, to Sept 28, 2023
- Multicentre
- Prospective near-patient subphenotyping
- 30 centres; enrolment Nov 22, 2019, to Sept 28, 2023
Main finding
As reported in the abstract
Hyperinflammatory vs HypoinflammatoryEstimate (95% CI)P value
60-day mortality
RR 1.8(1.4–2.4)
P < 0.0001After adjustment
aOR 2.7(1.6–4.4)
P = 0.0002Observational data: associations, not effects.
Further findings
Subphenotype prevalence (near-patient assay)
- Subphenotype prevalence (near-patient assay): 490 subphenotyped
Original publication
Bedside identification of subphenotypes in acute respiratory failure (PHIND): a multicentre, observational cohort study. Lancet Respir Med. Published 23 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →