Beyond the debut: unpacking six years of Hypotension Prediction Index software in intraoperative hypotension prevention - a systematic review and meta-analysis
Pooled result · TWA of MAP < 65mmHgResult — go to the resultMedian difference - 0.21 95% CI −0.33 to −0.09Authors' conclusion
While the combination of HPI software with personalized treatment protocols may prevent intraoperative hypotension (IOH), the large heterogeneity among the studies and the lack of reliable data on its clinical significance necessitate further investigation.
Study context
- Population
- Adults undergoing non-cardio/thoracic surgery under GA; studies published January 2018 to February 20249 RCTs and 5 cohort studies
- Comparison
- Hypotension Prediction Index (HPI)-guided management with personalized treatment protocol vs control
- Outcome
- Intraoperative hypotension: Time-Weighted Average (TWA) of Mean Arterial Pressure (MAP) < 65mmHg
Methodological detailsRoB 2 and ROBINS-I risk-of-bias assessment
- RoB 2 and ROBINS-I risk-of-bias assessment
Pooled result
TWA of MAP < 65mmHg
Median difference
- 0.21
95% CI −0.33 to −0.09
P < 0.001
HPI-guided vs Control
median difference - 0.21 (95% CI −0.33 to −0.09); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | Median difference (95% CI) | P value | |
|---|---|---|---|
| Incidence of hypotensive episodes per patientLarge heterogeneity among studies | −3.71 (−6.67 to −0.74) | P = 0.014 | |
| Duration of hypotensionLarge heterogeneity among studies | - 10.11 (−15.82 to −4.40) | P = 0.001 | |
| −20−10010Difference (linear scale) |
Original publication
Beyond the debut: unpacking six years of Hypotension Prediction Index software in intraoperative hypotension prevention - a systematic review and meta-analysis. J Clin Monit Comput. Published 24 July 2024. doi:10.
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