Cardiothoracic & vascular anesthesia
Blood bupivacaine concentrations after pecto-serratus and serratus anterior plane injections of plain and liposomal bupivacaine in robotically-assisted mitral valve surgery: Sub-study of a randomized trial
Authors' conclusion
Combined injection of plain and liposomal bupivacaine for pecto-serratus/serratus anterior plane blocks produced a biphasic pattern, with the highest arterial plasma concentrations observed within 30 min. Maximum concentrations exceeded the potential toxic threshold in nearly a third of patients, but without clinical evidence of toxicity.
Study context
- Population
- Adults undergoing robotically-assisted mitral valve surgery13 analysed
- Participants
- 18 adults
Primary result
As reported in the abstract
Geometric mean maximum bupivacaine concentration (range 660 to 4650 ng/ml), at median time of 30 min after injection
1492 ng/ml
Patients with plasma bupivacaine concentrations above the predefined 2000 ng/ml toxic threshold
4 of 13
31%
Safety
Signs of local anaesthetic toxicity
- No obvious signs of local anesthetic toxicity observed
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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