Hemodynamics, fluids & transfusion
Blood pressure control with phenylephrine or dobutamine: a randomized controlled trial comparing effects on cerebral and paravertebral tissue oxygen saturation measured with near-infrared spectroscopy
Authors' conclusion
Our data indicates that, when used for maintenance of blood pressure within a 20% range of preoperative values, neither phenylephrine nor dobutamine affect paravertebral tissue saturation.
Study context
- Population
- Patients receiving vasoactive support to maintain MAP within 20% of the preoperative value
- Participants
- 34 patients
- Comparison
- Phenylephrine vs dobutamine to keep MAP within 20% of preoperative value
- Primary endpoint
- Regional cerebral and paravertebral tissue oxygen saturation (rScO2, rSpvO2 at T3-T4, T9-T10, L1-L2) by near-infrared spectroscopy
Primary result
As reported in the abstract
Paravertebral tissue saturation (rSpvO2)
- No significant changes at the paravertebral level in either group; slight but statistically significant difference between groups at T3-T4 and L1-L2
Further findings
| Outcome | PE | Dobu |
|---|---|---|
| Change in cerebral tissue saturation (rScO2) | −14.1% (SD 16.1) | −5.9% (SD 10.6) |
| Change in MAP | −2% (SD 21) | - 19% (SD 17) |
| Change in cardiac index | −14.6% (SD 14.6) | 24.1% (SD 49.9) |
| Change in heart rate | −21% (SD 21) | 0% (SD 16) |
Change in cerebral tissue saturation (rScO2)
- Significant decrease in both groups, more pronounced with phenylephrine (PE)
Original publication
Blood pressure control with phenylephrine or dobutamine: a randomized controlled trial comparing effects on cerebral and paravertebral tissue oxygen saturation measured with near-infrared spectroscopy. J Clin Monit Comput. Published 17 May 2023. doi:10.
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