Hemodynamics, fluids & transfusion
Clinical outcomes and peripheral tissue oxygen saturation monitoring of the knee region by near-infrared spectroscopy in circulatory shock: a prospective observational cohort study
Authors' conclusion
Lower peripheral StO2 was associated with 90-day mortality in critically ill patients with circulatory shock but not with persisting or worsening organ dysfunction.
Study context
- Population
- Adults with circulatory shock within 24 h of intensive care units (ICU) admission, three ICUs, April 2019 to May 2023non-consecutive sample
- Participants
- 256 adults
- Exposure
- 48-h mean peripheral saturation (StO2) by Sequential Organ Failure Assessment (SOFA) improvement and 90-day survival
- SOFA-improversn = 171reference
- Non-improversn = 85
- Outcome
- Change in SOFA score, dichotomised to improvement or non-improvement (death within 7 days = non-improvement)
- Follow-up
- From enrollment to day 7 or ICU discharge
Methodological detailsmulticentre (three ICUs), Patient sample not consecutive, due to several reasons including the COVID-19 pandemic
- Multicentre (three ICUs)
- Patient sample not consecutive, due to several reasons including the COVID-19 pandemic
Main finding
As reported in the abstract
48-h mean StO2
P = 0.020
Observational data: associations, not effects.
Secondary outcomes
48-h mean StO2 and 90-day mortality (multivariable analysis)
| OR (95% CI) | P value | ||
|---|---|---|---|
| 48-h mean StO2Not associated with SOFA change | 0.97 (0.94–1.00) | P = 0.047 | |
| 0.512Odds ratio (log scale) |
48-h mean StO2 and 90-day mortality, excluding last 6 h of StO2 registration in patients who died during the 48 h registration (multivariable analysis)
| OR (95% CI) | P value | ||
|---|---|---|---|
| 48-h mean StO2n = 29 who died during registration; no longer significant | 0.97 (0.94–1.00) | P = 0.062 | |
| 0.512Odds ratio (log scale) |
Median
| Outcome | 90-day survivors | Non-survivors | P value |
|---|---|---|---|
| 48-h mean StO2 by 90-day survival | 68.7% (IQR 58.2–74.5) | 60.9% (IQR 49.5–67.1) | P < 0.001 |
90-day mortality, all patients
- 90-day mortality
- 27.0% (n = 69)
Areas below predefined StO2 thresholds
- No statistically significant differences between SOFA-improvers and non-improvers
- All areas larger in 90-day non-survivors
Original publication
Clinical outcomes and peripheral tissue oxygen saturation monitoring of the knee region by near-infrared spectroscopy in circulatory shock: a prospective observational cohort study. Crit Care. Published 19 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →