Hemodynamics, fluids & transfusion
Blood volume and hemodynamics during treatment of major hemorrhage with Ringer solution, 5% albumin, and 20% albumin: a single-center randomized controlled trial
Authors' conclusion
The power to expand the plasma volume was 4 and almost 12 times greater for 5% albumin and 20% albumin than for Ringer-lactate, and the effect was sustained over 5 h.
Study context
- Population
- Patients undergoing cystectomy with major hemorrhage
- Participants
- 42 patients
- Comparison
- 5% albumin or 20% albumin vs Ringer-lactate alone
- Primary endpoint
- Plasma volume expansion per infused volume (regression on blood hemoglobin)
- Follow-up
- 5 h
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Plasma volume expansion (times infused volume)
5% albumin
0.74
20% albumin
2.09
Ringer-lactate
0.18
Further findings
| Outcome | 5% albumin | 20% albumin | Ringer-lactate |
|---|---|---|---|
| Blood volume changeSlight hypovolemia with Ringer-lactate only | + 63 mL | - 44 mL | mean - 313 mL |
| Plasma volume expansion half timeMedian, h | 5.5 | 4.8 | — not stated in the abstract |
— not stated in the abstract
Central venous pressure
- Increase in central venous pressure with 5% and 20% albumin
Hemorrhage volume (all patients)
- Median hemorrhage, mL [IQR 615-1145]
- 848
Original publication
Blood volume and hemodynamics during treatment of major hemorrhage with Ringer solution, 5% albumin, and 20% albumin: a single-center randomized controlled trial. Crit Care. Published 5 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →