Cardiothoracic & vascular anesthesia
Comparison of 4% Albumin and Ringer's Acetate on Hemodynamics in On-pump Cardiac Surgery: An Exploratory Analysis of a Randomized Clinical Trial
Authors' conclusion
In on-pump cardiac surgery, hypotension and hyperlactatemia are associated with the occurrence of ≥1 MAE. Compared with Ringer's acetate, albumin did not decrease hypotension and decreased hyperlactatemia only late postoperatively.
Study context
- Population
- On-pump cardiac surgical patients, Helsinki University Hospital
- Participants
- 1,386 patients
- Comparison
- Albumin vs Ringer's
- Primary endpoint
- Incidence of hypotension (time-weighted average MAP <65 mmHg) and hyperlactatemia (time-weighted average blood lactate >2 mmol/L)
- Follow-up
- Operating room, early (0-6 h) and late (6-24 h) postoperatively
Methodological detailsdouble-blind, single-centre
- Double-blind
- Single-centre
Primary result
As reported in the abstract
P > 0.05
Further findings
Hypotension · early postoperatively (0-6 h)
P > 0.05
Hypotension · late postoperatively (6-24 h)
P > 0.05
Hyperlactatemia · operating room · after Bonferroni-Holm correction
P > 0.025
Hyperlactatemia · early postoperatively (0-6 h) · after Bonferroni-Holm correction
P > 0.025
Hyperlactatemia · late postoperatively (6-24 h)
P < 0.001
Overall counts (operating room, early, late postoperatively)
- Hypotension
- 118, 48, and 17 patients
- Hyperlactatemia
- 313, 131, and 83 patients
Association with ≥1 MAE (ALBICS primary outcome)
- Hypotension and hyperlactatemia associated with MAE occurrence
Original publication
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