Cardiothoracic & vascular anesthesia
Albumin and Cardioprotection in On-Pump Cardiac Surgery—A Post Hoc Analysis of a Randomized Trial
Authors' conclusion
Both endogenous and exogenous albumin appear to be cardioprotective regarding CK-MBm release in on-pump cardiac surgery.
Study context
- Population
- Adult on-pump cardiac surgical patients, Helsinki University Hospital
- Participants
- 1,386 patients
- Comparison
- 4% albumin vs Ringer's acetate for CPB priming and volume replacement
- Albuminn = 693
- Ringern = 693reference
Methodological detailsdouble-blinded, single-centre
- Double-blinded
- Single-centre
Primary result
As reported in the abstract
CK-MBm · first postoperative morning
Β (albumin administration, whole cohort)
−0.156
CI −0.201 to −0.111P < 0.001
Albumin vs Ringer
Β (high intraoperative albumin concentration, Ringer group)
−0.07
CI −0.140 to −0.003P = 0.04
Ringer
- Albumin's potency to reduce creatinine kinase-myocardial band mass (CK-MBm) vs ischaemia-induced increase, whole cohort (β-value ratio of −0.156/0.376)
- 41%
- Albumin's potency to reduce CK-MBm vs ischaemia-induced increase, Ringer group (β-value ratio of −0.07/0.363)
- 19%
Further findings
Plasma albumin concentration, preoperative · preoperatively
P = 0.171
Plasma albumin concentration, intraoperative (after protamine) · intraoperatively
P < 0.001
| Outcome | Estimate | P value |
|---|---|---|
| Aortic cross-clamping time association with CK-MBmWhole cohort | standardized β 0.376 (95% CI 0.315–0.437) | P < 0.001 |
| Aortic cross-clamping time association with CK-MBmRinger | β 0.363 (95% CI 0.273–0.452) | P < 0.001 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Albumin and Cardioprotection in On-Pump Cardiac Surgery—A Post Hoc Analysis of a Randomized Trial. J Cardiothorac Vasc Anesth. Published 23 September 2023. doi:10.
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