ICU sedation, delirium & recovery
Body composition-guided protein dosing in critically ill patients: a before-and-after study (PROGRESS-ICU)
Main finding · 90-day all-cause mortalityResult — go to the resultAdjusted hazard ratio 0.78 95% CI 0.56–1.09Authors' conclusion
In this observational before-after study, FFM-based protein dosing was not associated with differences in mortality compared with TBW-based dosing.
Study context
- Population
- Adult intensive care unit (ICU) patients with serial bioelectrical impedance analysis (April 2020-October 2025)310 per cohort
- Participants
- 620 patients
- Exposure
- Fat-free mass (FFM)-based vs total body weight (TBW)-based protein dosing
- FFMn = 310
- TBWn = 310reference
- Outcome
- All-cause mortality
- Follow-up
- 90 days
Methodological detailsinverse probability of treatment weighting, multivariable Cox regression, prespecified analyses
- Inverse probability of treatment weighting
- Multivariable Cox regression
- Prespecified analyses
Main finding
90-day all-cause mortality
Adjusted hazard ratio
0.78
95% CI 0.56–1.09
FFM-based vs TBW-based protein dosing
adjusted HR 0.78 (95% CI 0.56–1.09)
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| ICU LOSShorter ICU stay with FFM | 0.79 (0.69–0.91) | |
| IMV durationFewer IMV days with FFM | 0.79 (0.65–0.96) | |
| Hospital LOS | 0.86 (0.67–1.10) | |
| 0.512Hazard ratio (log scale) |
Urea-to-creatinine ratio (UCR) trajectories and FFM loss
- TBW dosing associated with higher UCR trajectories and greater FFM loss
Original publication
Body composition-guided protein dosing in critically ill patients: a before-and-after study (PROGRESS-ICU). Crit Care. Published 22 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →