Cardiac arrest & resuscitation
Brain-derived extracellular vesicles as serologic markers of brain injury following cardiac arrest: A pilot feasibility study
Authors' conclusion
This study explores the associations between miRNAs from neuron-derived EVs (NDEs) and circulating protein biomarkers within 6 hours with neurologic outcome, suggesting a panel of very early biomarker may be useful during clinical care.
Study context
- Population
- Patients resuscitated after out-of-hospital cardiac arrest (OHCA)9 with good outcome
- Participants
- 27 patients
- Outcome
- Association of miRNA from GluR2-positive serologic extracellular vesicles (EVs) with dichotomised mRS
- Follow-up
- Discharge
Methodological detailspilot feasibility study, Samples 7/3/2019 to 7/21/2022
- Pilot feasibility study
- Samples 7/3/2019 to 7/21/2022
Main finding
As reported in the abstract
miR-124 (EVs measured within 6 hours of resuscitation) vs mRS at discharge · within 6 hours of resuscitation
- AUC for miR-124
- 0.84
- Several micro-RNA (miRNA) species including miR-124 statistically associated with modified Rankin Score (mRS) at discharge
- p < 0.05
Observational data: associations, not effects.
Further findings
Kendall ranked correlation of miRNA associations
- miRNA associations with outcome not strongly correlated with standard serologic markers or amongst themselves
Original publication
Brain-derived extracellular vesicles as serologic markers of brain injury following cardiac arrest: A pilot feasibility study. Resuscitation. Published 15 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →