Caffeine administration to treat oversedation after general anesthesia: A retrospective analysis
Main finding · Sedation scores (first RASS score after PACU discharge)Result — go to the resultOdds ratio 1.13 95% CI 1.00–1.28Authors' conclusion
In this observational study, caffeine administration during anesthesia recovery was associated with improved sedation scores. However, it was also associated with an increased risk of respiratory complications, possibly reflecting selection bias (ie, administering caffeine to higher-risk patients).
Study context
- Population
- Adults admitted to the PACU after GA with postoperative sedation (RASS < 0), quaternary medical center, May 2018–December 2020
- Participants
- 47,222 adults
- Exposure
- Caffeine 250 mg vs no caffeine
- Caffeinen = 1,892
- Outcome
- Sedation scores (first RASS score after PACU discharge)
Methodological detailssingle-centre, inverse probability of treatment weighting
- Single-centre
- Inverse probability of treatment weighting
Main finding
As reported in the abstract
Odds ratio
1.13
95% CI 1.00–1.28
P = 0.04
Caffeine vs No caffeine
OR 1.13 (95% CI 1.00–1.28); P = 0.04
Observational data: associations, not effects.
Further findings
- Patients who received caffeine had more sedation in the PACU
Safety
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Respiratory complications · within 48 h after PACU dischargeIPTW-adjusted analysis | 2.99 (1.44–6.24) | P = 0.003 | |
| Emergency response team activationIPTW-adjusted analysis | 7.18 (2.85–18.10) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Caffeine administration to treat oversedation after general anesthesia: A retrospective analysis. J Clin Anesth. Published 15 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →