Cardiothoracic & vascular anesthesia
Carboxyhemoglobin as Potential Biomarker for Cardiac Surgery Associated Acute Kidney Injury
Main finding · CSA-AKIResult — go to the resultOdds ratio 1.45 95% CI 1.023–2.071Authors' conclusion
CO-Hb ≥ 1.4% at ICU admission is an independent risk factor for CSA-AKI, which is easily obtainable and available on routine arterial blood gas measurements.
Study context
- Population
- Adult on-pump cardiac surgery patients, July 2014 to June 2022, tertiary university-affiliated hospital
- Participants
- 1,698 patients
- Exposure
- Carboxyhemoglobin (CO-Hb) quartiles at intensive care unit (ICU) admission
- Outcome
- CSA-AKI
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Odds ratio
1.45
95% CI 1.023–2.071
P = 0.038
CO-Hb ≥ 1.4% vs CO-Hb < 1.0%
OR 1.45 (95% CI 1.023–2.071); P = 0.038
Observational data: associations, not effects.
Further findings
| Outcome | CO-Hb ≥ 1.4% | P value |
|---|---|---|
| Postoperative creatinine, CO-Hb ≥ 1.4% vs <1.4%Univariable analysis | 135 μmol/L | P < 0.001 |
| Postoperative RRT, CO-Hb ≥ 1.4% vs <1.4%Univariable analysis | 6.7% | P < 0.001 |
| AKI, CO-Hb ≥ 1.4% vs <1.4%Univariable analysis | P < 0.001 | |
| Time to AKI or death, CO-Hb ≥ 1.4% vs <1.4% | P < 0.001 |
- Postoperative creatinine, CO-Hb ≥ 1.4% vs <1.4%: CO-Hb <1.4% 116 μmol/L
- Postoperative RRT, CO-Hb ≥ 1.4% vs <1.4%: CO-Hb <1.4% 2.3%
AKI, CO-Hb ≥ 1.4% vs <1.4%
- Higher AKI rate with CO-Hb ≥ 1.4%
Time to AKI or death, CO-Hb ≥ 1.4% vs <1.4%
- Shorter time to AKI or death with CO-Hb ≥ 1.4%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Carboxyhemoglobin as Potential Biomarker for Cardiac Surgery Associated Acute Kidney Injury. J Cardiothorac Vasc Anesth. Published 10 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →